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Journal of Korean Neurosurgical Society > Volume 37(5); 2005 > Article
Journal of Korean Neurosurgical Society 2005;37(5): 370-374.
Hyperacute Radiation Effect on Cerebral Cortex after Local Gamma-irradiation in the Rat Brain.
Shin Hyuk Kang, Yong Gu Chung, Han Kyum Kim, Chul Yong Kim, Hoon Kap Lee
1Department of Neurosurgery, College of Medicine, Korea University, Seoul, Korea. hermes23@medimail.co.kr
2Department of Pathology, College of Medicine, Korea University, Seoul, Korea.
3Department of Radiooncology, College of Medicine, Korea University, Seoul, Korea.
We investigated the morphologic changes within 24 hours after a single gamma-irradiation in the rat brain.
Forty Sprague-Dawley rats were used. After a burr hole trephination on right parietal area, cerebral hemisphere was irradiated with 2Gy and 5Gy using iridium-192(192Ir), respectively. The effect was assessed at 4, 8, 12 and 24 hours after irradiation. The histological changes were scored following the detection of edema or disarray severity. TUNEL-positive cells exhibiting apoptotic morphology were counted in irradiated region.
Cortical edema and disarray were initially showed at 4 or 8hour and almost all defined at 24hour after irradiation. And the injury was wedge shape. TUNEL-positive cells were minimal at 8hour after irradiation as the number of positive cells were 2.6+/-5.27(n=5) after 2Gy, and 0.8+/-0.84(n=5) after 5Gy. But, the number of apoptotic cells were increased markedly to 60+/-6.24 at 12hour after 2Gy and to 104+/-19.7 at 24hour after 5Gy.
There were prominent morphologic changes immediately after gamma-irradiation. And, apoptosis was increased according to the time period. These findings implicate that brain irradiation induces rapid apoptotic change, which may play an important role in the pathogenesis of radiation-induced pathologic conditions.
Key Words: Cranial irradiation; Radiation injuries; Apoptosis; Rat
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