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Journal of Korean Neurosurgical Society 2006;39(2): 148-151.
Brain Metastasis from Dermatofibrosarcoma Protuberans.
Wook Ha Kim, Chul Kee Park, Dong Gyu Kim, Hee Won Jung
Department of Neurosurgery, Seoul National University College of Medicine, Clinical Research Institute, Seoul, Korea. hwnjung@snu.ac.kr
Dermatofibrosarcoma protuberans(DFSP) is an uncommon fibrohistiocytic tumor characterized by aggressive local invasion and consequent local recurrence rather than distant metastasis. We present a case of a 51-year-old male patient with a typical cutaneous DFSP, which showed local recurrences and distant metastasis to the central nervous system(CNS) and the lung after 15 years from the initial diagnosis. CNS metastatic lesions recurred in 5 months after surgical resection of the first CNS lesion. These metastatic tumors were treated by open surgery and gamma-knife radiosurgery. Despite continuous medication of oral chemotherapeutic agent, the patient died during 1-year follow-up period.
Key Words: Dermatofibrosarcoma protuberans; Brain metastasis
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