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Journal of Korean Neurosurgical Society 2006;39(3): 176-182.
Usefulness of 11C-Methyl-L-and D-Methionine PET in Gliomas: with Special Attention to Recurrence.
Won Sang Cho, Chi Heon Kim, Jeong Eun Kim, June Key Chung, Sun Ha Paek, Hee Won Jung
1Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea. jems7075@snu.ac.kr
2Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea.
3Department of Clinical Research Institute, Seoul National University College of Medicine, Seoul, Korea.
ABSTRACT
OBJECTIVE
This study concernes the usefulness of 11C-methyl-L-and D-methionine(Met)-positron emission tomography(PET) for gliomagrading and detection of recurrence in gliomas, compared with fluorine-18, 2-fluoro-deoxyglucose(FDG)-PET.
METHODS
Eighty patients underwent Met-PET study for evaluation of glioma: 37 astrocytomas (WHO grade II, 3; III, 8; IV, 26), 27 oligodendrogliomas (WHO grade II, 16; III, 11), and 12 suspicious recurrent gliomas. All images were taken within 2 weeks before operation. For suspicious recurrent cases on magnetic resonance images, both FDG-PET and Met-PET were performed.
RESULTS
In astrocytoma, Mean maximum standard uptake value(SUV) of region of interest(ROI) was not different between WHO grades (p=0.108), but ROI/normal contralateral tissue SUV (T/N) ratio was statistically different between WHO grades (p=0.002). T/N ratio was more closely related to visual scale than maximum SUV of ROI (p<0.001 and p=0.107 respectively). In oligodendroglioma, there was no statistical difference between WHO grades in view of maximum SUV and T/N ratio. For recurrent gliomas, sensitivity of FDG-PET and Met-PET was 25% and 100%, while specificity of FDG-PET and Met-PET were 100% and 80%, respectively.
CONCLUSION
Met-PET might be an appropriate tool for tumor grading in astrocytom a and be more sensitive for detection of recurrence in gliomas than FDG-PET.
Key Words: Methionine; Glioma; PET; Recurrence
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