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Journal of Korean Neurosurgical Society 2006;39(6): 409-412.
Novalis Radiosurgery of Primary Central Nervous System Lymphoma in Elderly Patients: Preliminary Results.
Seong Rok Han, Gi Taek Yee, Chan Young Choi, Moon Jun Sohn, Dong Joon Lee, Choong Jin Whang
Department of Neurosurgery, Ilsan Paik Hospital, College of Medicine, Inje University, Goyang, Korea. hsrkmj@ilsanpaik.ac.kr
Primary central nervous system lymphoma(PCNSL) is a non-Hodgkin's lymphoma arising in the central nervous system. Combined chemotherapy and radiation therapy is the standard treatment for PCNSL. However, treatment induced neurotoxicity is a major problem especially in elderly patients.
From May 2001 to April 2004, elderly five patients with PCNSL confirmed via pathological examination were underwent Novalis radiosurgery in authors' institution, who were investigated retrospectively. Of these patients, 2 were male and 3 were female, with a mean age 68 years old (range 65~73). The number of lesions was 1 in 2 patients, 2 in 2, and 3 in 1. The mean follow up period was 12.6 months (range 8~16).
Clinical symptoms and signs in all patients markedly improved within 1 weeks after Novalis radiosurgery. The Karnofsky performance status score was also improved from a pre-radiosurgery average of 68 to a post-radiosurgery one of 82. All of treated lesions showed a partial or complete regression of the original mass. There have been no complication following Novalis radiosurgery.
The preliminary results of our experience indicate that radiosurgery with Novalis provides a safe and effective therapeutic alternative treatment of PCNSL in elderly patients.
Key Words: Lymphoma; Elderly; Radiotherapy; Radiosurgery; Novalis
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