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Journal of Korean Neurosurgical Society > Volume 40(1); 2006 > Article
Journal of Korean Neurosurgical Society 2006;40(1): 54-57.
Central Nervous System Involvement of Acute Lymphoblastic Leukemia.
Seung Jae Hyun, Young Baeg Kim, Hyeon Yu, Hyun Jong Hong
1Department of Neurosurgery, College of Medicine, Chung-Ang University, Seoul, Korea. ybkim1218@cau.ac.kr
2Department of Diagnotic Radiology, College of Medicine, Chung-Ang University, Seoul, Korea.
ABSTRACT
Central nervous system(CNS) involvement of acute lymphoblastic leukemia may occur. However, CNS involvement as a first manifestation of leukemia is very rare. An 8-year-old girl complained of a backache after playing in the water. Neurological examination detected progressing paraparesis. Magnetic resonance imaging(MRI) of the thoracolumbar spine showed a well-circumscribed homogeneous posterior extradural mass lesion extending from T7 to T9. MRI of the brain showed diffused fatty marrow replacement of the calvarium and the skull base. We report a patient with epidural Burkitt's lymphoma of the thoracic and lumbar vertebra causing compression of the spinal cord after pathologic evaluation. The tumor consisted mainly of lymphoblastic cells, which were identical to those originally seen in the bone marrow aspiration and biopsy. After decompressive laminectomy she began consolidation chemotherapy.
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