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Journal of Korean Neurosurgical Society > Volume 41(3); 2007 > Article
Journal of Korean Neurosurgical Society 2007;41(3): 186-189.
doi: https://doi.org/10.3340/jkns.2007.41.3.186
Craniospinal Metastasis from a Metastasizing Mixed Tumor of Salivary Gland : Unusual Presentation.
Hyun Hee Ye, Chang Won Cho, Mi Young Jeon, Dae Jo Kim
1Department of Neurosurgery, Maryknoll Medical Center, Busan, Korea. braincwc@hotmail.com
2Department of Pathology, Maryknoll Medical Center, Busan, Korea.
ABSTRACT
Metastasizing mixed tumors (MMT) of salivary glands are inexplicably metastasize maintaining benign histology. There is no pathologic and flow cytometric analysis criteria to predict the metastasis. MMT is known to metastasize by local implantation, vascular and lymphatic embolization after multiple surgery to local recurrences of primary tumor. However, multiple metastasis including cranium and spine occurred even without surgery to the primary tumor in this case. No pathological evidence of malignancy could be found in both primary and metastatic tumor. MMT is considered as an low grade malignancy based on clinical behavior rather than histologic evidence, such as low mortality rate, long delay of metastasis after primary lesion. Cranial metastasis is also extremely rare and only two cases have been reported. We report this unusual case with a literature review.
Key Words: Metastasizing mixed tumors; Metastasis; Primary tumor; Cranial
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