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Journal of Korean Neurosurgical Society 2007;41(6): 408-410.
Paradoxical Deterioration of Intramedullary Spinal Tuberculomas during Antituberculous Therapy.
Keum Jun Jang, Cheol Su Jwa, Kang Hyun Kim, Jae Kyu Kang
Department of Neurosurgery, National Medical Center, Seoul, Korea. chsjwa@hanmail.net
"Paradoxical deterioration" during antituberculous therapy is generally defined as the clinical or radiological worsening of pre-existing tuberculous lesions or the development of new lesions in a patient who initially improves. The phenomenon of paradoxical deterioration in intramedullary tuberculoma of the spinal cord is rare and is a less established entity. The authors present an unusual case of paraparesis as a result of paradoxical deterioration of intramedullary tuberculoma despite adequate antituberculous therapy. Here, we review the relevant literatures and discuss its possible pathogenic mechanisms.
Key Words: Tuberculoma; Spinal cord; Antituberculous therapy
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