Gamma Knife Radiosurgery for Vestibular Schwannomas.

Lim, Young Jin; Choi, Seok Keun

Review

Journal of Korean Neurosurgical Society 2007;42(3): 159-167.

Department of Neurosurgery, School of Medicine, Kyunghee University, Seoul, Korea. youngjinns@yahoo.co.kr

ABSTRACT

Vestibular schwannoma (VS) is a benign tumor typically originated in the schwann cell of vestibular nerve and usually accompany hearing symptom. Microsurgical removal and radiosurgery have a great role for the treatment of VS. Recently radiosurgery has been considered as an alternative or primary treatment for VS with the tremendous increase of patients who were treated with gamma knife radiosurgery (GKS) though microsurgery still takes the premier. By many published results, it is proved that GKS is a effective and noninvasive technique for VS, especially small sized tumors with satisfactory tumor control rate. The authors assumed that GKS can be expected to achieve satisfactory tumor control rate for small VS under 5 cc in volume. A major interest regarding radiosurgery nowadays is to determine the optimal radiation dose for hearing preservation to improve the quality of life of patients. The more high radiation dose are used for effective tumor growth control, the more radiation-related complications like as hearing deficit, the impairment of other cranial nerve function are increased. Since 1990's the mean radiation dose for tumor margin was more than 18 Gy, but there were high complication rate in spite of good tumor growth control. After the year of 2000, under the influence of advanced neuro-imaging techniques and radiosurgical planning system which enable clinicians to do more precise planning, marginal dose for VS has been decreased to 12-13 Gy and the radiation-related complications has been reduced. But because there may be a unexpected radiationinduced complications as time goes by after the latency period, optimal radiation dose for VS should be established on the basis of more long term follow-up observation.

Key Words: Gamma knife radiosurgery; Vestibular schwannoma; Hearing preservation