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Journal of Korean Neurosurgical Society 2008;44(4): 273-276.
doi: https://doi.org/10.3340/jkns.2008.44.4.273
Skull Base Invasion of Adenoid Cystic Carcinoma of the Lacrimal Gland : A Case Report.
Jae Il Lee, Young Zoon Kim, Eun Hee Lee, Kyu Hong Kim
1Department of Neurosurgery, Masan Samsung Hospital, Sungkyunkwan University School of Medicine, Masan, Korea. youngzoon.kim@samsung.com
2Department of Pathology, Masan Samsung Hospital, Sungkyunkwan University School of Medicine, Masan, Korea.
ABSTRACT
Although adenoid cystic carcinoma (ACC) of the lacrimal gland is a rarely encountered orbital tumor, it invades intracranially more frequently than carcinomas of other glands in the head and neck. A 52-year-old man underwent orbital exenteration and resection of intracranially extended tumor via a fronto-orbito-zygomatic approach in combination with a transfacial approach. Histopathologically, the tumor showed perineural, vascular, and lymphatic invasion. Additionally, he received radiotherapy (60 Gy) and adjuvant systemic cisplatin and 5-fluorouracil chemotherapy due to residual tumor in the orbit and systemic metastases (lung, ribs, and spines). He was free of progression and recurrence at 6 months after treatment. The authors report a case of skull base invasion by an ACC of the lacrimal gland to remind neurosurgeons planning intervention that this disease shows a tendency to invade intracranially.
Key Words: Adenoid cystic carcinoma; Skull base; Metastasis; Prognosis
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