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Journal of Korean Neurosurgical Society > Volume 48(2); 2010 > Article
Journal of Korean Neurosurgical Society 2010;48(2): 99-104.
doi: https://doi.org/10.3340/jkns.2010.48.2.99
Impact of Early Enteral Nutrition on In-Hospital Mortality in Patients with Hypertensive Intracerebral Hemorrhage.
Jeong Shik Lee, Cheol Su Jwa, Hyeong Joong Yi, Hyoung Joon Chun
1Department of Neurosurgery, National Medical Center, Seoul, Korea. chsjwa@hanmail.net
2Department of Neurosurgery, Hanyang University Medical Center, Seoul, Korea.
ABSTRACT
OBJECTIVE:
We conducted this study to evaluate the clinical impact of early enteral nutrition (EN) on in-hospital mortality and outcome in patients with critical hypertensive intracerebral hemorrhage (ICH).
METHODS:
We retrospectively analyzed 123 ICH patients with Glasgow Coma Scale (GCS) score of 3-12. We divided the subjects into two groups : early EN group (< 48 hours, n = 89) and delayed EN group (> or = 48 hours, n = 34). Body weight, total intake and output, serum albumin, C-reactive protein, infectious complications, morbidity at discharge and in-hospital mortality were compared with statistical analysis.
RESULTS:
The incidence of nosocomial pneumonia and length of intensive care unit stay were significantly lower in the early EN group than in the delayed EN group (p < 0.05). In-hospital mortality was less in the early EN group than in the delayed EN group (10.1% vs. 35.3%, respectively; p = 0.001). By multivariate analysis, early EN [odds ratio (OR) 0.229, 95% CI : 0.066-0.793], nosocomial pneumonia (OR = 5.381, 95% CI : 1.621-17.865) and initial GCS score (OR = 1.482 95% CI : 1.160-1.893) were independent predictors of in-hospital mortality in patients with critical hypertensive ICH.
CONCLUSION:
These findings indicate that early EN is an important predictor of outcome in patients with critical hypertensive ICH.
Key Words: Enteral nutrition; Intracerebral hemorrhage; Mortality
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