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Journal of Korean Neurosurgical Society 2010;48(3): 301-304.
doi: https://doi.org/10.3340/jkns.2010.48.3.301
Metronidazole Induced Encephalopathy in a Patient with Brain Abscess.
Yoochang Bahn, Eunyoung Kim, Chongoon Park, Hyung Chun Park
Department of Neurosurgery, Inha University Hospital, Inha University College of Medicine, Incheon, Korea. nskey@inha.ac.kr
Metronidazole is commonly used for brain abscess but is not well known for its neurotoxic complications. Metronidazole-induced encephalopathy (MIEP) is toxic encephalopathy associated with the use of metronidazole. We experienced a case of brain abscess which developed reversible severe MIEP during treatment period. Although MIEP occurs in typical locations, it is not easy to differentiate from other conditions such as cerebral infarction, demyelinating diseases and metabolic diseases. Neurosurgeons should be aware that severe MIEP can occur during the use of metronidazole though it is not common.
Key Words: Metronidazole; Brain abscess; Toxic encephalopathy
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