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Journal of Korean Neurosurgical Society > Volume 49(1); 2011 > Article
Journal of Korean Neurosurgical Society 2011;49(1): 8-12.
doi: https://doi.org/10.3340/jkns.2011.49.1.8
Association of Toll-Like Receptor 5 Gene Polymorphism with Susceptibility to Ossification of the Posterior Longitudinal Ligament of the Spine in Korean Population.
Won Suk Chung, Dong Hyun Nam, Dae Jean Jo, Jun Hwan Lee
1Department of Oriental Rehabilitation Medicine, College of Oriental Medicine, Kyung Hee University, Seoul, Korea. omdjun@khnmc.or.kr
2Department of Biofunctional Medicine and Diagnostics, College of Korean Medicine, Sang Ji University, Wonju, Korea.
3Department of Neurosurgery, School of Medicine, Kyung Hee University, Seoul, Korea.
ABSTRACT
OBJECTIVE:
Ossification of the posterior longitudinal ligament (OPLL) has a strong genetic component. Specific gene polymorphisms may be associated with OPLL in several genes which regulate calcification in chondrocytes, change of extracellular collagen matrix and secretions of many growth factors and cytokines controlling bone morphogenesis. Toll-like receptor 5 (TLR5) may play a role in the pathogenesis of OPLL by intermediate nuclear factor-kappa B (NF-kappaB). The current study focused on coding single nucleotide polymorphisms (SNPs) of TLR5 for a case-control study investigating the relationship between TLR5 and OPLL in a Korean population.
METHODS:
A total of 166 patients with OPLL and 231 controls were recruited for a case-control association study investigating the relationship between SNPs of TLR5 gene and OPLL. Four SNPs were genotyped by direct sequencing (rs5744168, rs5744169, rs2072493, and rs5744174). SNP data were analyzed using the SNPStats, SNPAnalyzer, Haploview, and Helixtree programs. Multiple logistic regression analysis with adjustment for age and gender was performed to calculate an odds ratio (OR).
RESULTS:
None of SNPs were associated with OPLL in three alternative models (codominant, dominant, and recessive models; p > 0.05). A strong linkage disequilibrium block, including all 4 SNPs, was constructed using the Gabriel method. No haplotype was significantly associated with OPLL in three alternative models.
CONCLUSION:
These results suggest that Toll-like receptor 5 gene may not be associated with ossification of the posterior longitudinal ligament risk in Korean population.
Key Words: OPLL; TLR5 gene; Polymorphisms; Genetic association study
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