Journal of Korean Neurosurgical Society

Hyperactivity of mTORC1- and mTORC2-dependent signaling mediates epilepsy downstream of somatic PTEN loss

Erin R Cullen, Mona Safari, Isabelle Mittelstadt, Matthew C Weston

Hyperactivity of mTORC1- and mTORC2-dependent signaling mediates epilepsy downstream of somatic PTEN loss

Erin R Cullen, Mona Safari, Isabelle Mittelstadt, Matthew C Weston

Seizures exacerbate excitatory: inhibitory imbalance in Alzheimer’s disease and 5XFAD mice

Aaron J Barbour, Sarah Gourmaud, Eunjoo Lancaster, Xiaofan Li, David A Stewart, Keegan F Hoag, David J Irwin, Delia M Talos, Frances E Jensen

Focal cortical dysplasia II caused by brain somatic mutation of IRS-1 is associated with ERK signaling pathway activation

Xiao Li, Tianshuang Wang, Nana Liu, Aojie Cai, Junjiao Zhang, Fan Zhang, Qingzhu Liu, Jingmin Wang, Ye Wu, Kai Gao, Yu-Wu Jiang

Modeling mTORopathy-related epilepsy in cultured murine hippocampal neurons using the multi-electrode array

Anouk M. Heuvelmans, Martina Proietti Onori, Monica Frega, Jeffrey D. de Hoogen, Eveline Nel, Ype Elgersma, Geeske M. van Woerden

Experimental Neurology.2024; 379: 114874. CrossRef

Innovative drug discovery strategies in epilepsy: integrating next-generation syndrome-specific mouse models to address pharmacoresistance and epileptogenesis

Expert Opinion on Drug Discovery.2024; 19(9): 1099. CrossRef

The clinico‐pathological characterisation of focal cortical dysplasia type IIb genetically defined by MTOR mosaicism

Yajie Wang, Tao Yu, Ingmar Blümcke, Yanning Cai, Ke Sun, Runshi Gao, Yujiao Wang, Yongjuan Fu, Wei Wang, Yuping Wang, Guojun Zhang, Yueshan Piao

Neuropathology and Applied Neurobiology.2023;[Epub] CrossRef

Antitumor Potential of Antiepileptic Drugs in Human Glioblastoma: Pharmacological Targets and Clinical Benefits

Manuela Stella, Giammarco Baiardi, Stefano Pasquariello, Fabio Sacco, Irene Dellacasagrande, Alessandro Corsaro, Francesca Mattioli, Federica Barbieri

Socrates: A Novel N-Ethyl-N-nitrosourea-Induced Mouse Mutant with Audiogenic Epilepsy

Elena G. Varlamova, Ekaterina V. Borisova, Yuliya A. Evstratova, Andrew G. Newman, Vera P. Kuldaeva, Maria S. Gavrish, Elena V. Kondakova, Victor S. Tarabykin, Alexey A. Babaev, Egor A. Turovsky

International Journal of Molecular Sciences.2023; 24(23): 17104. CrossRef

CfDNA Measurement as a Diagnostic Tool for the Detection of Brain Somatic Mutations in Refractory Epilepsy

Sonia Mayo, Irene Gómez-Manjón, Francisco Javier Fernández-Martínez, Ana Camacho, Francisco Martínez, Julián Benito-León

International Journal of Molecular Sciences.2022; 23(9): 4879. CrossRef

Increased glycine contributes to synaptic dysfunction and early mortality in Nprl2 seizure model

Brianne Dentel, Lidiette Angeles-Perez, Chongyu Ren, Vikram Jakkamsetti, Andrew J. Holley, Daniel Caballero, Emily Oh, Jay Gibson, Juan M. Pascual, Kimberly M. Huber, Benjamin P. Tu, Peter T. Tsai

Cortical neuronal hypertrophy and mTOR pathway activation in CAN regions in SUDEP

Smriti Patodia, Yau Mun Lim, Freda Chung, Irene Stylianou, Hanaa El Hachami, Maria Thom

Pharmacotherapy for SARS-CoV-2 and Seizures for Drug Repurposing Presumed on Mechanistic Targets

Divya Goel, Ankit Srivastava, Ángel Aledo-Serrano, Anuja Krishnan, Divya Vohora

Current Molecular Pharmacology.2022; 15(6): 832. CrossRef

4E-BP2–dependent translation in parvalbumin neurons controls epileptic seizure threshold

Vijendra Sharma, Rapita Sood, Danning Lou, Tzu-Yu Hung, Maxime Lévesque, Yelin Han, Jeremy Y. Levett, Peng Wang, Shravan Murthy, Shannon Tansley, Siyan Wang, Nadeem Siddiqui, Soroush Tahmasebi, Kobi Rosenblum, Massimo Avoli, Jean-Claude Lacaille, Nahum So

Proceedings of the National Academy of Sciences.2021;[Epub] CrossRef

Convergent and Divergent Mechanisms of Epileptogenesis in mTORopathies

Rapamycin alleviates memory deficit against pentylenetetrazole-induced neural toxicity in Wistar male rats

Fatemeh Aghaie, Afsaneh Shemshaki, Mojgan Rajabi, Parisa Khatami, Abdolkarim Hosseini

Molecular Biology Reports.2021; 48(6): 5083. CrossRef

Application of single cell genomics to focal epilepsies: A call to action

Non-synaptic Cell-Autonomous Mechanisms Underlie Neuronal Hyperactivity in a Genetic Model of PIK3CA-Driven Intractable Epilepsy

Achira Roy, Victor Z. Han, Angela M. Bard, Devin T. Wehle, Stephen E. P. Smith, Jan-Marino Ramirez, Franck Kalume, Kathleen J. Millen

Frontiers in Molecular Neuroscience.2021;[Epub] CrossRef

Advances in genetic testing and optimization of clinical management in children and adults with epilepsy

Marcello Scala, Amedeo Bianchi, Francesca Bisulli, Antonietta Coppola, Maurizio Elia, Marina Trivisano, Dario Pruna, Tommaso Pippucci, Laura Canafoglia, Simona Lattanzi, Silvana Franceschetti, Carlo Nobile, Antonio Gambardella, Roberto Michelucci, Federic

Expert Review of Neurotherapeutics.2020; 20(3): 251. CrossRef

Therapeutic role of targeting mTOR signaling and neuroinflammation in epilepsy

Novel therapeutic targets in epilepsy: oxidative stress and iron metabolism

Neuropathology and Applied Neurobiology.2020; 46(6): 519. CrossRef

Mechanistic target of rapamycin (mTOR) implicated in plasticity of the reproductive axis during social status transitions

Karen P. Maruska, Young Chang Sohn, Russell D. Fernald

General and Comparative Endocrinology.2019; 282: 113209. CrossRef

Brain somatic mutations in MTOR reveal translational dysregulations underlying intractable focal epilepsy

Jang Keun Kim, Jun Cho, Se Hoon Kim, Hoon-Chul Kang, Dong-Seok Kim, V. Narry Kim, Jeong Ho Lee

Journal of Clinical Investigation.2019; 129(10): 4207. CrossRef

Astrocytes: Role and Functions in Brain Pathologies

Rosalba Siracusa, Roberta Fusco, Salvatore Cuzzocrea