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Journal of Korean Neurosurgical Society 1983;12(4): 521-528. |
| Acute Effect of Methylprednisolone in Experimental Spinal Cord Injury. |
| Dae Whan Kim, Kyu Man Shin |
| Department of Neurosurgery, Ewah Womans University, College of Medicine, Seoul, Korea. |
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| ABSTRACT |
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It is the purpose of this study to determine the benificial effect of treatment with methylprednisolone on the enhancement of Na+, K+-ATPase activity and the increased ATP level during the 4 hours after a 400gm-cm injury to the spinal cord of cat. These results demonstrate that high dose (30mg/kg) of methylprednisolone can benificially enhance the activity of neuronal Na+, K+-ATPase during the first 4 hour after spinal cord injury. But the enhancement of this enzyme activity is not significantly increased with mega dose (60mg/kg) of methylprednisolone. Tissue level of ATP in the high dose-treated cat at 1 hour after trauma was significantly elevated, but those in high dose-treated cat at 4 hour and the 1 and 4 hours with mega dose-treated groups were not significantly increased. The protective effects of methylprednisolone in experimental spinal cord trauma are the enhancement of Na+, K+-ATPase, inhibition of the free-radical reaction and the lipid peroxidation, the increment of neuronal activity and ATP utilization. High dose(30mg/kg) of methylprednisolone is required in order to produce the acute effect in the early phase experimental spinal cord injury. |
| Key Words:
Spinal cord injury; Methylprednisolone; ATP; Na+, K+-ATPase |
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